FGF23 and heart failure: In such analyses, there was no association of genetically predicted FGF-23 with higher risk of coronary artery disease (1.06; 95% CI, 0.95 to 1.18), ischemic stroke (0.82; 95% CI, 0.65 to 1.03), or heart failure (0.82; 95% CI, 0.68 to 0.98; Figure 1).