The genesis and progression of CKD in persons with type 2 diabetes (T2D) involvings hemodynamic factors (arterial hypertension and increased intraglomerular pressure), metabolic factors (poor glycemic control), and overactivation of the mineralocorticoid receptor (MR) which promotes inflammation and fibrosis, ultimately leading to alterations at the cardiac, vascular and renal levels [20,21]. Here, NR3C2 is linked to chronic kidney disease.