LDLR and Hypercholesterolemia: Notably, the arteries in Ldlr KO or aged mice on chow did not show changes in the adventitial area, or the major vascular cell populations (Figure 5C–E, Supplementary material online, Table S8), or any sign of atherosclerotic plaque development compared with C57Bl/6J, as expected in only mild hypercholesterolaemia and ageing (Figure 5C and D).