Ageing preferentially increased CD55+ PDGFRA+ and CXCL14+ PDGFRA+ cell fractions, whereas mild dyslipidaemia in Ldlr KO mice only increased the LOX+ PDGFRA+ cell fraction, representing the fibrosis-associated trajectory (Figure 5A and B, Supplementary material online, Table S7), suggesting the context-dependent importance of the inferred trajectories in the progression of the disease. This evidence concerns the gene LDLR and inherited lipid metabolism disorder.