CD55 and atherosclerosis: As an indicator of the most differentiated cluster in Trajectory 1, complement decay-accelerating factor (Cd55) (Figure 4A) is involved in complement activation and a whole-body KO mouse presented with a protective phenotype against atherosclerosis.31,32 The marker representing Trajectory 2, chemokine ligand 14 (Cxcl14) (Figure 4A), is involved in immune regulation and immune cell migration.33 Lastly, the marker representing Trajectory 3, Lox, is involved in the crosslinking and stabilization of extracellular matrix34 (Figure 4A).