The second largest multicenter prospective study by Sammour et al.29reported that peritoneal IL‐6 is helpful for early postoperative AL diagnosis on POD 1, whereas the first largest multicenter prospective study by Sparreboom et al.35found that peritoneal IL‐6 has no significance in early postoperative AL detection on the first 3 days following rectal cancer resection. Here, IL6 is linked to rectal cancer.