● Knockout of Ikkε gene promotes improvement of whole-body metabolic status by decreasing the inflammatory cytokines expression and increasing the energy drainage. This also alters the expression of glucose- and lipid-metabolizing enzymes. ● As the absence of IKKε resolves the obesity-linked metabolic complications associated with insulin resistance and T2D, it can be used as therapeutic target for recovery in future. The gene discussed is IKBKE; the disease is Insulin resistance.