A causal relationship between ECM and inflammation in obesity was highlighted by evidences of augmented collagen VI α3 subunit mRNA along with enhanced macrophage chemotaxis and M1 ATM prevalence in obese human subjects, which was eventually lowered upon treatment with the thiazolidinedione (TZD)-type antidiabetic drug, pioglitazone [97]. Here, ATM is linked to obesity due to melanocortin 4 receptor deficiency.