FOXO3 and central nervous system cancer: Since FTO has been reported to serve as a tumor suppressor in gliomas by interacting with FOXO3a, enhancing FOXO3a nuclear translocation and target gene expression[29], in this study, FTO regulation of FOXO3a nuclear translocation and the expression levels of reported FOXO3a targets (BIM, BNIP3, BCL-6, and PUMA) were investigated.