In the PPI network, S100A9, S100A8, TLR4, S100A12, ENSSSCP00000027312, TRAF6 and CYBB proteins had higher BC scores of 31.81, 25.36, 20.98, 20.82, 16.34, 15.89, and 13.72, respectively. This evidence concerns the gene TLR4 and breast cancer.