In the PPI network, S100A9, S100A8, TLR4, S100A12, ENSSSCP00000027312, TRAF6 and CYBB proteins had higher BC scores of 31.81, 25.36, 20.98, 20.82, 16.34, 15.89, and 13.72, respectively. The gene discussed is S100A8; the disease is breast cancer.