Except for two subtypes with too few cells (Retnla+ macrophages and Hcar2+ macrophages), we found that the subtypes mainly existing in tumor tissues were more tended to M2 polarization, including the Spp1+, Clqb+, Ifitm6+, and Facn1+ macrophages (Figure 5F). This evidence concerns the gene HCAR2 and neoplasm.