PTEN and nonpapillary renal cell carcinoma: Since EMT could be modulated by multiple signaling pathways, including PTEN/Akt [31], Wnt/β-Catenin [32], PI3K/Akt [33], and MAPK [34], we first speculated whether ADAM12 induced EMT progression through the EGFR/RAS signaling pathway in ccRCC.