Taking together, ADAM12 acts to facilitate the EGFR/ERK signaling pathway and enhance the function to activate c-Myc and EMT-related molecules such as E-cadherin, N-cadherin and Snail, leading to the induction of EMT and the promotion of ccRCC growth and metastasis. This evidence concerns the gene EGFR and nonpapillary renal cell carcinoma.