The present study showed that TgCRND8 mice had significantly higher expressions of C/EBPβ and AEP in the hippocampus than the WT mice, and these elevated protein levels were reversed upon PA treatment, indicating that the anti-AD effects of PA may be mediated via inhibiting the activation of C/EBPβ/AEP signaling pathway. The gene discussed is CEBPB; the disease is Alzheimer disease.