MAPT and Alzheimer disease: Furthermore, the overexpression of C/EBPβ enhanced the expression of AEP-cleaved tau N368 proteolytic fragments, tau hyperphosphorylation and Aβ level to a greater extent than that seen with control virus-treated TgCRND8 mice, and all these AD-like pathogenesis induced by C/EBPβ were substantially ameliorated upon PA treatment.