KDR and metastatic melanoma: Examples include vascular endothelial growth factor receptor 2 (VEGFR-2) in metastatic melanoma and other solid tumors [120, 121], VEGFR-1 in lung cancer [122], αvβ3 integrin in metastatic melanoma [123], αvβ6 integrin in cholangiocarcinoma (CCA) [124], ovarian, breast and pancreatic cancer [125].