First, a limited number of predictive factors were available from SEER program data when this nomogram was developed, such as hepatitis B reactivation after chemoimmunotherapy, Child score of liver function or postoperative AFP level, etc. Second, postoperative adjuvant therapy was unknown (such as targeted therapy, immunotherapy or interventional therapy), we cannot consider the change in postoperative adjuvant therapy during the study; therefore, no assessment of the potential impact of postoperative adjuvant therapy on the nomogram can be made. This evidence concerns the gene AFP and hepatitis B virus infection.