For example, a patient with moderately differentiation, the tumor size is 4 cm, AFP is positive, and cirrhosis would have a total of 133 points (36 points for differentiation, 8 points for tumor size, 42 points for AFP, and 47 points for Fibrosis), the survival probability of 1-year, 3-year and 5-year is about 85%, 60%, and 45%, respectively. The gene discussed is AFP; the disease is fibrosis.