Notably, we identified a transcription factor YBX1 (Y-box binding protein-1, YB-1), which was upregulated in myeloma cells with low immune reactive status (Additional file 1: Fig. S13A), and showed negative correlation with MHC class I molecules expression, whereas positive correlation with expressions of immunosuppressive genes including LGALS1 and TGFB1 (Additional file 1: Fig. S13B). Here, YBX1 is linked to plasma cell myeloma.