On the contrary, the frequency of TIM3+ CD8+ T cells showed a significant decrease after knocking down YBX1 in myeloma cells (Additional file 1: Fig. S15D), which was consistent with the decreased expression of LGALS9 in RPMI-8226 with YBX1 knockdown (Additional file 1: Fig. S14C), whereas other exhausted markers remained unchanged (Additional file 1: Fig. S15E). This evidence concerns the gene CD8A and plasma cell myeloma.