TGFB1 and plasma cell myeloma: By comparing myeloma cells in pre-treated samples with post-treated samples both in responders and non-responders, we found genes and pathways involving TGFβ signaling and cell adhesion were downregulated after treatment, while stress-associated genes and pathways (e.g., apoptosis, reactive oxygen species) showed upregulated after treatment both in responders and non-responders (Additional file 1: Fig. S8E, F).