Consistently, gene set enrichment analysis (GSEA) on CoMMpass cohort revealed that multiple biological processes, including hematopoietic stem cell differentiation, mTORC1 signaling, MYC target, cell cycle were upregulated in MM highly expressed YBX1 compared with low-YBX1 group (Fig. 6D). The gene discussed is MYC; the disease is Miyoshi myopathy.