Conversely, the tumor microenvironment associated with Luminal cancers of Cluster 2 showed a more high infiltration of regulatory T cells (Tregs), Plasmacytoid Dendritic Cells (PDCs), Common Lymphoid Progenitors, Macrophages M0 and M1, CD4+ Th1 cells, and CD4+ Th2 cells, as well as, a higher cytotoxicity score. This evidence concerns the gene CD4 and cancer.