Moreover, we found that CD276 expression was positively correlated with immune checkpoint genes in the LGG, LIHC, PCPG and THCA cancer types, including TGFBR1 [transforming growth factor beta (TGF-beta) receptor 1], TGFB1 (transforming growth factor beta 1), NECTIN2 (poliovirus receptor-related protein 2), IL10RB (interleukin 10 receptor beta) and CSF1R (colony-stimulating factor-1 receptor) (Fig. 12B). This evidence concerns the gene NECTIN2 and cancer.