We explored the single-cell immunity module in the TIGER database to analyze the expression of CD276 in various types of cancer and their corresponding immune cells, and found that the expression level of CD276 was higher in basal cell carcinoma and breast cancer; moreover, the expression level of CD276 in fibroblasts was the highest in basal cell carcinoma, and the expression level of CD276 was also strong in melanocytes and fibroblasts in breast cancer. This evidence concerns the gene CD276 and breast cancer.