CD276 and central nervous system cancer: First, the expression profile of CD276 in cancer was analyzed using the CancerSEA database, and it was found that the expression level of CD276 in various cancer types was high, including brain higher-grade glioma (HGG), ovarian serous cystadenocarcinoma (OV), glioma, GBM and breast invasive carcinoma (BRCA) (Fig. 2A).