Moreover, it was found that the DNA methylation level of CD276 was observably decreased in almost all types of cancers in the UALCAN database, including BLCA, LIHC, LUAD, LUSC, PCPG and TGCT (Supplementary Figs. S4A and E-2I), and these decreases were statistically significant. The gene discussed is CD276; the disease is cancer.