High levels of TGs in plasma reduce the number and activity of insulin receptors on adipocytes and prevent insulin from binding to receptors by competing with glucose to enter cells, leading to diabetes, while lower HDL levels also lead to decreased insulin secretion and sensitivity [30].Abnormal blood lipid levels may cause insulin resistance (IR) by causing inflammation, endoplasmic reticulum stress and lipotoxicity [31]. The gene discussed is INSR; the disease is Insulin resistance.