Animals were treated with irradiation and immunotherapy (as defined in Fig. 2a), and divided into four groups as follows: control animals with tumor inoculations but no further treatment (n = 6); animals treated with RT 8 Gy × 2 (n = 6); animals treated with intratumoral anti-C1-INH (n = 6) and animals treated with both RT 8 Gy × 2 + anti-C1-INH (n = 5). Here, SERPING1 is linked to neoplasm.