Although hereditary pancreatitis genes are often not included in multigene panels, probably due to a biologically different mechanism of these genes in PanC development, the presence of mutations in CFTR has been associated with a modest increased risk for PanC, with affected appear to be diagnosed at a younger age, especially among smokers (McWilliams et al. 2010, 2005; Wilschanski and Durie 2007; Durno et al. 2002; Cazacu et al. 2018). The gene discussed is CFTR; the disease is hereditary chronic pancreatitis.