In our study, BRCA2 mutations were identified in 4 unselected PanC patients including two patients under the 50 years with positive family history for breast cancer who carried a pathogenic mutation (c.2244C > G and c.6037A > T, respectively), and two 64-years old patients with positive family history for PanC and endometrial cancer who carried a pathogenic-likely pathogenic or a pathogenic mutation (c.8755-1G > A and c.8954_8955delTTinsAA, respectively). This evidence concerns the gene BRCA2 and breast carcinoma.