CD8A and neoplasm: In addition, we found significantly increased T cell accumulation in tumors, spleen and draining lymph nodes in B16-OVA tumor-bearing mice in which ↑[H+]-expanded cells had been adoptively transfererd as compared with that in mice that received control cells, suggesting that CD8+ T cells maintained in ↑[H+] have improved persistence (Fig. 5c–e and Extended Data Fig. 9d).