In addition, miRNAs play a significant role in lipid metabolism beyond cholesterol, and also in insulin signalling in the liver, thus contributing to the pathways that are often dysregulated in metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), which are closely linked to CAD6. The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.