By combining observations from the Reactome, KEGG and GO pathway enrichment analyses we observed that miRNAs down-regulated in the stable CAD patients compared to the acute CAD patients and controls are involved in regulation of e.g. peroxisome proliferator-activated receptor alpha (PPARα) activated gene expression, insulin resistance, insulin signalling and sphingolipid signalling pathways (Fig. 5A,B). This evidence concerns the gene INS and coronary artery disorder.