The level of circSCMH1, Plpp3, LPP3, and FTO were further measured after EC-specific FTO overexpression, showing that EC-specific FTO overexpression attenuated the decreased expression of FTO and Plpp3/LPP3 after PT stroke, whereas had no effect on the ischemia-induced circSCMH1 decrease (Supplementary Fig. 12a–e). This evidence concerns the gene FTO and ischemia.