In contrast to CD8+ TRbpj-KD (Fig. 2c-d), CD8+ TRIN1 promoted tumor growth, and this positive effect was inhibited by anti-PD-1 antibody, indicating that RIN1 in vitro did not simulate the protective effect of CD8+ TRbpj-KD (Supplementary Fig. 4d-e). The gene discussed is RIN1; the disease is neoplasm.