Although RBPJ was not associated with patients’ HBV infection, tumor size, and liver cirrhosis (Supplementary Fig. 14), patients in RBPJhigh expression group exhibited shorter overall survival, disease-free survival outcomes, and progression free interval (Supplementary Fig. 13d), and higher pathological grade, stage (Supplementary Fig. 13e) than in RBPJlow expression group. This evidence concerns the gene RBPJ and cirrhosis of liver.