(2) L-kynurenine attenuated the activation of HCCRIN1-sup on CD8+ T cells (Fig. 5g–j, Supplementary Fig. 7a–d), indicating that the enhanced function of HCCRIN1-sup-CD8 was attributed to the decreased secretion of L-kynurenine from HCC cells. Here, CD8A is linked to hepatocellular carcinoma.