Since RIN1 (Fig. 1J-K) and inhibition of Rbpj (Fig. 2) were able to improve the function of HCC infiltrating CD8+ T cells, we used mass cytometry by the time-of-flight (cyTOF) to comprehensively analyze the remodeling effect of RIN1 on T cells in vivo. The gene discussed is CD8A; the disease is hepatocellular carcinoma.