Although RBPJ was not associated with patients’ HBV infection, tumor size, and liver cirrhosis (Supplementary Fig. 14), patients in RBPJhigh expression group exhibited shorter overall survival, disease-free survival outcomes, and progression free interval (Supplementary Fig. 13d), and higher pathological grade, stage (Supplementary Fig. 13e) than in RBPJlow expression group. Here, RBPJ is linked to neoplasm.