Serum TNF-α, IL6, IL1β and MCP-1 levels have been identified upregulated in obese mice and modulated by adipocyte TRPM7 knockout in our study, indicating that adipocyte TRPM7 might be regulated by aberrant cytokines with coupled positive-plus-negative feedback circuits in response to obesity. The gene discussed is TRPM7; the disease is obesity due to melanocortin 4 receptor deficiency.