TRPM7 and obesity due to melanocortin 4 receptor deficiency: First, considering that TRPM7-dependent macrophage inflammation has been reported in recent years and that adipose tissue inflammation involves complex mechanisms other than adipocyte dysfunction, such as recruitment of adipose-resident macrophages and T cells, which are regulated by a plethora of immunological and metabolic factors, it remains to be determined whether TRPM7 in inflammatory cells controls adipose tissue inflammation or functions synergistically with adipocytes during obesity development.