First, considering that TRPM7-dependent macrophage inflammation has been reported in recent years and that adipose tissue inflammation involves complex mechanisms other than adipocyte dysfunction, such as recruitment of adipose-resident macrophages and T cells, which are regulated by a plethora of immunological and metabolic factors, it remains to be determined whether TRPM7 in inflammatory cells controls adipose tissue inflammation or functions synergistically with adipocytes during obesity development. The gene discussed is TRPM7; the disease is Obesity.