Notably, weight loss in the HFD-fed ATKO mice was not related to the changes in food intake compared to the HFD-fed Flox mice (Fig. 1n), suggesting that the resistance of adipocyte-specific TRPM7 knockout mice to diet-induced obesity was attributed to higher catabolic rates. This evidence concerns the gene TRPM7 and obesity due to melanocortin 4 receptor deficiency.