CD274 and neoplasm: Therefore, we speculate that the damage caused by SV in CD274 UTR region is much more severe than that caused by SNP (Fig. 3a, b), and structural variation in CD274 UTR region might induce two post-transcriptional regulation molecular mechanism, one is that the higher efficient promoter fusing with the 5' UTR region and activating mRNA transcription; the other is that the miRNA binding site in the 3' UTR region is deleted, both leading to increased expression of PD-L1 protein and immune escape behavior of tumor cells (Supplementary Fig. 4).