Our most recent studies also validate that SOX2 is significantly upregulated in ESCC, and SOX2 transcriptionally regulate the expression of NRSN2-AS1 and KTN1-AS1, which promote ESCC cells proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) [26, 27]. The gene discussed is NRSN2; the disease is esophageal squamous cell carcinoma.