It was first showed in human BT549 triple-negative breast cancer (TNBC) cells and 4T1 mouse TNBC cells that acute CIN induction effectively activated the cGAS-STING signaling, resulting in the increased phosphorylation of STAT1, STAT3, and IRF3. Here, STING1 is linked to cervical squamous intraepithelial neoplasia.