In a recent study published in Nature, Hong et al. revealed that the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway is critically required for the IL-6-dependent survival of chromosomally unstable cancer cells,1 implying that chronic inflammation can be therapeutically targeted to kill cancers displaying chromosomal instability (CIN). The gene discussed is CGAS; the disease is cancer.