The expression of several autophagy genes is enhanced in muscles of KI AR113Q mice, with increased levels of LC3 and of SQSTM1/p62 [46]; similar data were obtained in SBMA patients [43], we also found that SQSTM1/p62 and LC3 protein levels are greatly increased in early symptomatic SBMA muscle, but notably bicalutamide impacts on their accumulation by restoring a proper autophagic activation or flux as supported by the analysis of HSPB8 levels. Here, HSPB8 is linked to Kennedy disease.