One of these is flutamide, a non-steroidal AR antagonist that was found beneficial in three SBMA mouse models [25]; instead, dutasteride, a 5alpha-reductase inhibitor that converts testosterone to a more potent androgen (dihydrotestosterone), did not modify disease progression in SBMA patients, even if some benefits were reported, such as a reduced tendency to fall [26]. The gene discussed is AR; the disease is Kennedy disease.