The pronounced synovial PRL expression in our RA patient agrees with Tang et al. findings; they attributed this to possible partial vascular leakage of the pituitary originated hormone into synovial tissue and from peripheral monocytes capable of PRL production, PRL and its receptors were suggested to be linked to RA pathology by local crosstalk (either by autocrine or paracrine ways), between the immune and endocrine systems [32, 35]. Here, PRL is linked to rheumatoid arthritis.