Currently, obesity diagnostics are based on standardized phenotypical body characteristic parameters: body mass index, BMI (≥ 30 kg/m2), body weight, waist circumference [7] and clinical parameters, such as plasma lipid profile, glycated hemoglobin, insulin, and fasting glucose levels to determine obesity comorbidities [8]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.