CD8A and infection: However, at 3 days post-infection (d.p.i), recruitment of B and T cells, encompassing both CD4+ and CD8+ subsets, was significantly reduced in the cKO mice compared with WT (Fig 6D–I), demonstrating that FAM21 cKO from CD11c+ dendritic cells of mice impacts multiple innate immune cell functions, and downstream B- and T-cell activation, upon C. albicans infection.