It is possible that some blood cancers, such as Philadelphia chromosome acute lymphoblastic leukemia and acute myeloid leukemias, which are known to induce IL7 down-regulation in bone marrow MSCs (Fistonich et al, 2018; Baryawno et al, 2019; Zehentmeier & Pereira, 2019) exploit molecular mechanisms, like LTβR, to prevent normal blood cell development and in this way reduce competition for limiting nutrients in the bone marrow interstitium. This evidence concerns the gene LTBR and hematopoietic and lymphoid system neoplasm.