IL7 and hematopoietic and lymphoid system neoplasm: It is possible that some blood cancers, such as Philadelphia chromosome acute lymphoblastic leukemia and acute myeloid leukemias, which are known to induce IL7 down-regulation in bone marrow MSCs (Fistonich et al, 2018; Baryawno et al, 2019; Zehentmeier & Pereira, 2019) exploit molecular mechanisms, like LTβR, to prevent normal blood cell development and in this way reduce competition for limiting nutrients in the bone marrow interstitium.