Interestingly, when expressed together, pp220 and pp62 interact with each other to form core shell-like structures that, as also occurs in pp220-transfected cells or in restrictive vEP84Ri infections, bind mainly to the cell surface and endosomal-lysosomal membranes [24, 29], but not to the ER membranes that sustain ASFV assembly. Here, DOK1 is linked to infection.