IL6R and Sepsis: In IVW MR analyses using the cisCRP instrument, we found evidence that CRP may be a part of the IL6R blockade effect, with evidence of reduced odds of sepsis and sepsis-related mortality: OR for sepsis outcome (0.91, 95% CI 0.82 to 1), OR for sepsis critical care admission (0.88, 95% CI 0.65 to 1.17), OR for death (0.72, 95% CI 0.59 to 0.93), OR for critical care death (0.58, 95% CI 0.32 to 1.04) (Fig 4 and S6 Table).