SNCA and Anxiety: Interestingly, in Thy1-aSyn mice, where SNCA expression appears in the PNS and the CNS simultanously, there is still late onset of dopamine loss at 14 months, but early onset of non-motor symptoms (e.g., deficits in olfaction, gastrointestinal dysfunction, sleep alterations, cognitive dysfunction, anxiety phenotype, Fig. 3) [43, 76–82].