Hsp90, several co-chaperones (CHIP, Hop, Aha1, Cdc37, FKBP51, p23, etc.)and client proteins of Hsp90 have been implied in neurodegenerative disease onset and progression ﻿(Koopman and Rüdiger 2020; Takeuchi et al. 2017), including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). This evidence concerns the gene HSP90AA1 and early-onset autosomal dominant Alzheimer disease.