SPP1 and head and neck cancer: Additionally, the PI3K-AKT pathway was also modulated via the regulation of 24 genes (Supplementary 2) (MAPK1, HGF, CCND1, MDM2, PIK3CA, IGF1R, TP53, ERBB2, EGFR, MET, STK11, MTOR, FASLG, MCL1, PTEN, TLR4, JAK2, SPP1, YWHAZ, BCL2, CDKN1A, IL6, BRCA1, VEGFA) which is the downstream pathway in the head and neck cancer for the EGF substrate, insulin growth factor I/II, hepatocyte growth factor (HGF) which acts through the EGFR, IGFRI, and c-MET, respectively.