Our study reported the modulation of PD-L1 expression and PD-1 checkpoint pathway in cancer via 14 different genes (MAPK1, CSNK2A1, IFNG, PIK3CA, STAT3, EGFR, PDCD1, STAT1, MTOR, PTEN, TLR4, CD274, JAK2, and HIF1A) (Supplementary 2). The gene discussed is HIF1A; the disease is cancer.