KRT88P and hepatocellular carcinoma: In contrast to HBV replicon-transfected hepatoma cells that are well known to secrete large quantities of naked capsids (6), HBV-infected HepG2-huNTCP cells released few such naked capsids (Fig. 3; Fig. S2), possibly because HBc expression in the replicon-transfected hepatoma cells is much higher than that from cccDNA in HBV-infected HepG2-huNTCP cells.