Interestingly, HBc was also detectable from cells infected with the HBV C(-)+HBc inoculum (Fig. 3A, top), indicating that some of the input HBc from the incoming virions (or naked capsids that are routinely released from HBV DNA-transfected hepatoma cells used to make the inoculum) remained associated with the cells (either on the cell surface or inside the cells) for at least 8 days. The gene discussed is KRT88P; the disease is hepatocellular carcinoma.