TIMP1 and Familial prostate cancer: Another limited analysis, of the three genes MMP-2, MMP-9 and TIMP-1 in human prostate cancers, showed no significant relationship between mRNA and protein expression levels (25).Therefore, we compared the protein activation effect of our CRISPR/dCasRx-SINEB2 with that of CRISPR activation (CRISPRa), which boosts transcription of a target gene and the overexpression vector.