To clarify the link between the Lrp2 gene and high-myopia, a mouse line, which contains homozygous floxed Lrp2 allele, is crossed with eighter the Best1-Cre or the Chx10-Cre transgenic mice to inactivated Lrp2 in RPE cells (Lrp2RPE KO) or the neural retina (Lrp2Retina KO), respectively. The gene discussed is BEST1; the disease is myopia.