VHL and myopia: Based on abnormal choriocapillaris development and decreased Vegf expression in RPE cells in Lrp2 conditional gene KO mice, we used von Hippel–Lindau (Vhl) and Vegf RPE-specific KO mice compared to lens-induced myopia (LIM) mice (30) to confirm that VEGF plays an essential role in proper choriocapillaris development and AL maintenance.