Height less than 2 SDS, diagnosis of T1DM after 18 years of age, evidence of diabetic retinopathy, neuropathy of nephropathy; intake medications, hormones, vitamins, or calcium in the preceding 6 months aside from insulin or thyroid hormones, no chronic disease, no hospitalization or DKA in the preceding months, no restriction of physical activity. This evidence concerns the gene INS and type 1 diabetes mellitus.