Our multicenter study supports an association of BRAF V600E with extrathyroidal extension (68.6% vs. 31.4%; p<0.001) and lymph node metastasis (64.8% vs. 35.2%; p=0.004), but not with distant metastasis (42.9% vs. 57.1%; p=0.163). This evidence concerns the gene BRAF and metastatic malignant neoplasm in the lymph nodes.