BGLAP and osteoporosis: Among major side effects of glucocorticoids there are the suppression of osteocalcin (OCN) and alkaline phosphatase (ALP) expression, the induction of osteoclastogenesis and of bone resorption, and the impairment of osteoblastogenesis and osteoblastic activity, all causing severe bone loss and, consequently, osteoporosis (54).