In contrast, it should be emphasized that the expression of only DPYSL4, MMP3, HTRA3, PDX1, C21orf29, and ATHL1 proteins was ever observed in the cytoplasm/membrane by IHC staining analysis among HCC patients, of which the expression of DPYSL4, MMP3, and ATHL1 proteins was clearly detected in all involved samples. This evidence concerns the gene TSPEAR and hepatocellular carcinoma.