have examined the combination of three G129R-hPRL based fusion proteins, which include G129R-hPRL fusions with endostatin (an angiogenesis inhibitor), interleukin 2 (immune modulator), and PE38KDEL (a truncated cytotoxin) in allografts of a mammary carcinoma cell line (McNeuA) derived from MMTC-neu mice (53). The gene discussed is COL18A1; the disease is breast carcinoma.