Using cBioPortal online database (http://www.cbioportal.org/), We found that there were significant differences in ITGB2 methylation in IDH WT and mutation gliomas (P < 0.0001, Figure S1A), The mRNA expression of ITGB2 was also significantly different in MGMT methylated and unmethylated gliomas(P < 0.0001, Figure S1B). Here, MGMT is linked to central nervous system cancer.