Notably, the levels of four inflammatory cytokines, including complement component C5/C5α, CXCL12/SDF-1, MIF, and Serpin E1/PAI-1, were significantly elevated in overweight PCOS compared with those in non-overweight PCOS based on our Protein microarray analysis, and this is the first report on the correlation different inflammatory cytokines’ correlation with the BMI of PCOS. The gene discussed is SERPINE1; the disease is polycystic ovary syndrome.