Like LDLR KO and ApoE KO mice, SR-B1 KO mice developed extensive atherosclerosis in normally susceptible arterial sites such as the aortic sinus and aortic arch; however, under the feeding conditions used, female SR-B1 KO mice also developed higher levels of atherosclerosis than corresponding ApoE or LDLR KO mice along the entire length of their descending aortas as well as in coronary arteries. This evidence concerns the gene SCARB1 and atherosclerosis.