Despite this, we observe, consistent with other reports, that whole body SR-B1 KO increased susceptibility of mice to atherosclerosis development, in this case triggered by the HFCC diet, and that the levels of atherosclerosis, at least under the conditions (diet and feeding time) employed herein, were comparable to those observed in ApoE KO and LDLR KO mice. The gene discussed is LDLR; the disease is atherosclerosis.