When SR-B1 is additionally knocked out in ApoE-mutant or LDLR KO mice, the resulting double KO mice are uniquely susceptible to development of occlusive coronary artery atherosclerosis and myocardial infarction causing early death (Braun et al., 2002; Zhang et al., 2005; Fuller et al., 2014). The gene discussed is SCARB1; the disease is myocardial infarction.