SCARB1 and atherosclerosis: On the other hand, others have demonstrated that SR-B1 mediates transcytosis of LDL across endothelial cells from the lumen to the sub-endothelial space of arteries and that endothelial selective KO of SR-B1 protected mice against atherosclerosis development (Armstrong et al., 2015; Ghaffari et al., 2018; Huang et al., 2019; Ghaffari et al., 2021).