APOE and atherosclerosis: Like LDLR KO and ApoE KO mice, SR-B1 KO mice developed extensive atherosclerosis in normally susceptible arterial sites such as the aortic sinus and aortic arch; however, under the feeding conditions used, female SR-B1 KO mice also developed higher levels of atherosclerosis than corresponding ApoE or LDLR KO mice along the entire length of their descending aortas as well as in coronary arteries.