We demonstrate that atherosclerotic plaque size in the aortic sinus of SR-B1 KO mice after 20 weeks of HFCC is similar to that of LDLR KO and ApoE KO mice, while atherosclerosis in the descending aorta and coronary arteries is significantly higher in SR-B1 KO mice. The gene discussed is APOE; the disease is atherosclerosis.