Analysis of spheroid formation confirmed that intercellular adhesion decreased as a result of both ELOVL5 and IGFBP6 knockdowns, thus suggesting that malignant breast tumors with reduced expression of ELOVL5 or IGFBP6 gene may metastasize more actively due to more efficient tumor cell invasion (Nikulin et al., 2021). This evidence concerns the gene IGFBP6 and neoplasm.