It has been reported that SLE is independently associated with genes in the Xq28 region including the interleukin-1 receptor associated kinase 1 gene (IRAK1), and its adjacent methyl CpG binding protein 2 (MECP2) and transmembrane protein 187 (TMEM187) genes (9–11). Here, IRAK1 is linked to systemic lupus erythematosus.