To show the overall influence of the HS-5 variants on CLL cell survival we determined the AUC as follows: wt HS-5 cells (7,488), scr control (6,912), CD248-deficient HS-5 cells (5,472), and the CLL monoculture (4,668) confirming that CD248 from HS-5 cells contributes at least in part to the survival support of primary CLL cells. This evidence concerns the gene CD248 and B-cell chronic lymphocytic leukemia.